In number cases, couple infertility results of an oligoasthenozoospermia without any recognized etiology. Hormone workup (LH, FSH, prolactin, and testosterone) was normal. To assess the effectiveness and safety of fixed dose combination (FDC) of antioxidants in treatment of idiopathic oligoasthenozoospermia, a large-scale placebo-controlled, Double-blind, randomized, Parallel three arm, Multicentric trial is conducted. Semen freeze-thawing procedures can be harmful for the function, quality, viability, and fertility of sperms [].The cryopreservation process can potentially impair the function and quality of sperms through the production of reactive oxygen species (ROS) which cause a decrease in antioxidant . Introduction. Setting: Fertility clinics of five centers across India. Yishen Tongluo formula (YSTLF), created by Professor Sun Zixue, has been used to treat oligoasthenozoospermia in clinical practice for several decades with a good therapeutic effect. Achieving natural pregnancy with oligoasthenozoospermia . Steroids may be used to treat infertility caused by an immune system problem. Based on the cause of oligospermia, Seeds of innocence determine the course of treatment suitable for the individual suffering from this medical condition. Oligoasthenozoospermia as less number of sperms and lower motility were found, compared to normal semen analysis. They did not receive any medication for infertility and had no . As people's lifestyle changes and the population ages, the incidence of oligoasthenozoospermia continues to increase. In number cases, couple infertility results of an oligoasthenozoospermia without any recognized etiology. It has been reported that, in approximately one third of infertile patients the cause of OA is un- A 30 years old male who had been diagnosed as Oligoasthenozoospermia with low sperm count and Non-motile spermatozoa with 5 years of married life and his wife with regular periods and anovulatory cycles, were treated successfully with Ayurvedic mangement. Introduction: To assess the effectiveness and safety of fixed dose combination (FDC) of antioxidants in treatment of idiopathic . Oligoteratozoospermia is a common condition (affecting nearly one in six men) and a leading cause of subfertility and infertility. The present paper summarizes the literature from domestic and international databases about acupuncture treatment of oligoasthenozoospermia, and offers an overview of the effects of acupuncture on the reproductive endocrine system, testicular blood flow, semen quality, and rate of conception in the treatment of the patient. In recent years, a boom in assisted reproductive technology (ART) has solved certain fertility problems; however, there are still some defects, such as adverse reac- Fixed Dose Combination Therapy of Antioxidants in Treatment of Idiopathic Oligoasthenozoospermia: Results of a Randomized, Double-blind, Placebo-controlled Clinical Trial Some studies demonstrate an improvement of spermatic parameters without taking physiological variations into consideration and without comparing the results with those obtained in . Various medical therapies have been proposed in the literature to increase sperm count and their mobility. 1998;5(4):361-363. So, patient was diagnosed with Oligoasthenozoospermia (KshinaShukra) and admitted in IPD of Panchakarma, IPGT & RA hospital for treatment. 1 Male infertility accounts for almost half of the infertility cases. Acupuncture has been applied for treating male infertility for several thousand years in China, but clinical evidence of its efficacy and safety in treating oligoasthenozoospermia is yet to be established. Medicine Formula Wuzi Yanzong Pill for the Treatment of Oligoasthenozoospermia: A Meta-Analysis of Randomized Controlled Trials MingPengZhao ,1 XiaoShi,1 GraceWingShanKong,1 ChiChiuWang,1 JustinCheYuenWu,2 ZhiXiuLin ,3,4 TinChiuLi,1 andDavidYiuLeungChan 1 Human‐Chorionic‐Gonadotropin (HCG) a week intramuscularly for twelve weeks. The effectiveness of TEAS alone for the treatment of oligoasthenozoospermia needs to be further investigated in well-designed studies. The median degree, betweenness, closeness, and k-core were used as the screening values to screen the core targets of QXF in the treatment of oligoasthenozoospermia. The main treatments include general treatment, endocrine therapy, anti-infective therapy, surgical treatment, and assisted reproductive technology (ART). Unfortunately, effective drug therapy is still lacking except for assisted reproductive technology (ART). Matsumiya K, Kitamura M, Kishikawa H, et al A prospective comparative trial of a gonadotropin-releasing hormone analogue with clomiphene citrate for the treatment of oligoasthenozoospermia. According to our data, we cannot recommend administration of antioxidant treatment with vitamins C and E for the treatment of unselected men with asthenozoospermia or moderate oligoasthenozoospermia. In spite of a decreased . Treatment may range from lifestyle changes to hormonal (antioxidant/ medication) and surgical methods (varicocele, microsurgery, etc.). Introduction Infertility is defined by the World Health Organization (WHO) as the inability of a couple to achieve conception or bring pregnancy to term after 1 year or more of regular . Among male sterility factors, oligoasthenozoospermia is the most common. " Previous researchers found that Wuzi Ershen decoction (WZESD) can increase sperm count, enhance sperm vitality, and improve semen quality. How to cite this article Gopinath PM, Kalra B, Saxena A, Malik S, Kochhar K, Kalra S, Zaveri H. Fixed Dose Combination Therapy of Antioxidants in Treatment of Idiopathic Oligoasthenozoospermia . Treatment with vitamin A and other OTC supplements (vitamin C, vitamin E, selenium, NAC, zinc, etc) has been demonstrated to improve motility by 30% (P 5.023) after 13 weeks of treatment (Scott et al, 1998) and improve the odds of having a normal sperm count (median sperm counts increased by 18.16 million [P 5 The most common cause of male infertility is idiopathic oligoasthenozoospermia. Treatment of Oligoasthenozoospermia with Tranilast, a Mast Cell Blocker, After Long-Term Administration Created Date: 10/16/2002 9:06:04 PM . Europe PMC is an archive of life sciences journal literature. Many clinical trials have . Oligoasthenozoospermia significantly increased serum FSH levels and decreased that of GnRH, T, LH, and E2 relative to the control group, which were restored by WZYZ formula (p<0.01) as well as methyltestosterone (p<0.05 for FSH; p<0.01 for other hormones) treatment. 25 Patients are treated with hCG, as described previously, until testosterone becomes normal and no further . If a semen analysis finds that you have low sperm count and poor motility, but your doctor can't explain why you're having this problem, he may diagnose you with idiopathic oligoasthenozoospermia. The clinical genetics and hormonal status of the 46,XX male is well determined. PDF | Intracytoplasmic sperm injection (ICSI) is a widely used and accepted treatment of choice for oocyte fertilization. Therefore, the study of apoptosis-related proteins such as p-ERK/ERK, p-AKT/AKT, Caspase-3, and Bcl-2 and Bax is of significance and may be a potential mechanism of PGG in the treatment of oligoasthenozoospermia. Low sperm count, quality, and motility is the cause of a staggering 90% of male infertility. It was approved by As we all know that 15-20% of couples suffer from the issues of infertility, however, 50% of . A previous laboratory had detected in the husband's semen just one immotile spermatozoon (oligoasthenozoospermia) and the gynaecologist advised the couple to proceed to ivf with donor sperm, instead of telling the partner to consult an urologist-andrologist. A prospective comparative trial of a gonadotropin-releasing hormone analogue with clomiphene citrate for the treatment of oligoasthenozoospermia. ALA plays a role in the treatment of oligozoospermia. My husband is diagnosed with oligoasthenozoospermia can you please suggest me treatment and its actual cause.-For the improvement of the semen 1. 01/01/1990 - "Because of the good results achieved with tamoxifen in the treatment of oligozoospermia and with kallikrein in the treatment of asthenozoospermia, a randomized study of the combined treatment of oligoasthenozoospermia suggested itself. Rolf C, Cooper TG, Yeung CH, Nieschlag E. Antioxidant treatment of patients with asthenozoospermia or moderate oligoasthenozoospermia with high-dose vitamin C and vitamin E: a randomized, placebo-controlled, double-blind study. The usual treatment regimen is 6,000 to 8,000 IU of hCG three times a week for 24 weeks. Further large-scale randomized controlled trials investigating the effects of TKM therapy for male infertility are needed. Some studies demonstrate an improvement of spermatic parameters without taking physiological variations into consideration and without comparing the results with those obtained in . Acupuncture has been applied for treating male infertility for several thousand years in China, but clinical evidence of its efficacy and safety in treating oligoasthenozoospermia is yet to be established. When a treatment for oligoasthenospermia is available, it should, if possible, be chosen over the use of ART. Physical examination, transrectal ultrasonography, and pelvic magnetic resonance imaging (MRI) demonstrated left seminal vesicle cyst, left renal agenesia, and contralateral seminal vesicle hypoplasia. The main treatments include general treatment, endocrine therapy, anti-infective therapy, surgical treatment, and assisted reproductive technology (ART). The Virtual Health Library is a collection of scientific and technical information sources in health organized, and stored in electronic format in the countries of the Region of Latin America and the Caribbean, universally accessible on the Internet and compatible with international databases. 2 Oligoasthenozoospermia (OA) is clearly amongst the most common forms of male infertility, which arises under circumstances that the total sperm . This study was designed as a prospective, randomized, single-blind, placebo-controlled trial. These treatment options include: Surgery Varicocele often require surgery. Pre‐treatment basal levels of FSH, LH and testosterone were in normal or low normal range. 16 males responded to therapy, the total motility of spermatozoa increased significantly from 34% to 40%. Treatment Plan: If ART are chosen without considering the male treatment, we may actually be shifting the burden of a male patient's treatment toward the female partner. Treatment will depend on the cause of your OAT. Relax and r. The aim of this study was to evaluate any possible effects of combining vitamin E as antioxidant and clomiphene citrate as. Machine translation. The therapeutic effects of a traditional chinese medicine formula wuzi yanzong pill for the treatment of oligoasthenozoospermia: A meta-analysis of randomized controlled trials. For the treatment of oligoasthenozoospermia, modern medicine mainly treats the primary cause and the application of various hormones. Fixed Dose Combination Therapy of Antioxidants in Treatment of Idiopathic Oligoasthenozoospermia: Results of a Randomized, Double-blind, Placebo-controlled Clinical Trial Fixed Dose Combination of Ceftazidime Plus Tobramycin Acts as Free Radical Scavenger in Liver of Mus musculus Mice Summary: 30 patients with isolated asthenozoospermia received a treatment with 5000 I.U. Oligoasthenozoospermia (OA), also called oligoasthenospermia, is a primary cause of male infertility where two seminal parameters are altered: sperm count and sperm motility. Clomid is one possible treatment option. Empirical medical treatment for idiopathic male infertility is still a controversial issue. They will then discuss treatment options and create a treatment plan. D-Tryptophan-6-LH-RH was assessed in the treatment of patients with normogonadotropic oligoasthenozoospermia in 18 subjects selected on the basis of at least 3 spermiograms, long standing infertility, normal LH, FSH, prolactin and testosterone serum levels and lack of evidence of any other pathologic involvement. Virechana karma was done as per classics. Sperm Pentox Therapy The Sperm Pentox Therapy is the therapy which enhances the characteristic features of sperms during the treatment of oligoasthenozoospermia with the use of Pentoxifylline. Oligoasthenozoospermia is the most common reason for male infertility. A 27-year-old man presented with chronic hematospermia, painful ejaculation, and primary infertility. You may have any of the following: Medicines may be given to treat an infection. Int J Urol. Kallikrein was given to 45 men 600 units daily in a period of 3-6 months. Conceiving with oligoasthenozoospermia Basically, there exist two fertility treatments that are adequate for these males: Intrauterine Insemination (IUI) Only indicated in cases of mild-to-moderate O, since there are a series of minimum quality standards to meet for IUI to be possible. Artificial insemination is contraindicated in cases of poor sperm motility. The primary treatment of oligoasthenospermia is far less expensive than ART [ 1, 2 ]. 2002). oligoasthenozoospermia was successfully included. Hormones may be used to treat a hormonal imbalance. Compared with the positive control, During the procedure, your doctor will close off the enlarged. The review article focus on the effect of homeopathy on male infertility based on sperm count, hormone values and general health. the healthy women recruited had male partners who were infertile and diagnosed with defective sperm function,such as asthenozoospermia, oligoasthenozoospermia, severe oligoasthenozoospermia and azoospermia, defined according to guidelines published by the World Health Organization. However, the chemical and pharmacological profiles of YSTLF remain unclear and need to be elucidated. [10,11] Hormone medications mainly include. Compared with the disease model group, the sperm quality of mice receiving treatment was significantly better (P<0.05 for all parameters, Figure 1). This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. These targets were imported into the STRING database to construct PPIs, and their topological features were analyzed using MCODE and entiscape plug-ins of Cytoscape. Infertility affects nearly 60 to 80 million couples worldwide, which is defined as the inability to conceive after 12 months of regular unprotected intercourse. 1.Introduction. Oligoasthenozoospermia is a common factor leading to male infertility. sottolinea che callicreina è un farmaco relativamente buona per il ripristino della motilità spermatica in idiopatica oligoasthenozoospermia e astenozoospermia. We studied the rate of spontaneous pregnancies among 85 married couples who between mid-1996 and December 1997 underwent 119 ICSI treatment cycles due to severe idiopathic oligoasthenozoospermia. Physical examination, transrectal ultrasonography, and pelvic magnetic resonance imaging (MRI) demonstrated left seminal vesicle cyst, left renal agenesia, and contralateral seminal vesicle hypoplasia. Hormone workup (LH, FSH, prolactin, and testosterone) was normal. When a man is asthenozoospermic and therefore is unable to get his wife or partner pregnant, the most recommendable treatment option is In Vitro Fertilization ( IVF ), either conventional or using ICSI (Intracytoplasmic Sperm Injection). How many men suffer from Oligoteratozoospermia? For the treatment of oligoasthenozoospermia, modern medicine mainly treats the primary cause and the application of various hormones. Keywords: This study investigated the pharmacological effects of astragalin for treatment of . The general health of patients improved significantly. This study represents TKM therapy including acupuncture and/or herbal remedies might be an option for infertile men (oligoasthenozoospermia). Data sources include IBM Watson Micromedex (updated 6 Dec 2021), Cerner Multum™ (updated 1 Jan 2022), ASHP (updated 13 Dec 2021 .