OBJECTIVE: To assess whether serum cTnT level could be a useful marker for the early detection of anthracycline-induced cardiotoxicity. BackgroundAnthracycline therapy is limited by cardiotoxicity. This study (n=208) aims to use echocardiography, strain imaging, holter monitoring and MRI for early detection of cardiomyopathy. Epub 2015 May 6. Circulation 2015;131:1981-1988. 2015;131(22):1981-8. Several studies have examined the use of myocardial relaxometry techniques in animal models of anthracycline-induced cardiotoxicity to detect early cardiac injury and to elucidate the progressive changes associated with CTRCD [ 27, 28, 29 ]. Significant reduction in LV ejection fraction as defined for cardiotoxicity occurred in only 3 of 10 patients (30%) with a cardiac event. Various methods have been. Mornos C, Petrescu L. Early detection of anthracycline-mediated cardiotoxicity: the value of considering both global longitudinal left ventricular strain and twist. However, detection of early changes via blood biomarkers for better risk stratification in humans remains challenging 3. Circulation 2015;131:1981-8. Probably, anthracycline-induced cardiotoxicity is a continuous phenomenon that starts from myocardial cell injury; it is followed by left ventricular ejection fraction (LVEF) and, if not diagnosed and cured early, progressively leads to symptomatic heart failure. While several biomarkers have been investigated, troponin I has the greatest evidence of detecting changes in left ventricular function early. However, LVEF is known to be a rather insensitive measure of early cardiac damage7 and several studies suggest that in anthracycline induced cardiotoxicity diastolic changes precede systolic dysfunction,8 9 as in other forms of heart disease.10 11 Thus the assessment of diastolic function may be a better method of early detection of cardiotoxicity. Anthracycline chemotherapy serves an important role in treating patients with breast cancer but is associated with cardiotoxicity. Early Detection of Anthracycline-Induced Cardiotoxicity in Breast Cancer Survivors. Yu Kang et al, Detection of anthracycline-induced cardiotoxicity ction (LVEF) using noninvasive cardiac imaging is the most important clinical diagnostic tool in early recognition of cardiac dysfunction [3, 4]. Early detection and prompt therapy of cardiotoxicity appear crucial for substantial recovery of cardiac function. Early detection and prompt therapy of cardiotoxicity appear crucial for substantial recovery of cardiac function. Echocardiography has been recommended by European Society of Cardiology as part of routine surveillance of cardiotoxicity ( 6 ). 2007 Early Detection of Anthracycline Cardiotoxicity in Rabbits 537 beginning of the study) were used in this study. February 24, 2021. Cardiotoxicity was detected at the 3-month time point in 1 patient (immediately after anthracyclines), whereas 8 other patients developed cardiotoxicity at the 6-month time point. Am J Cardiol 87:1120-1122, A1129. The remaining rabbits were randomly selected to create groups 1-4. However, they are somewhat insensitive in detecting early signs of cardiac stress, myocardial injury, and changes in myocardial compliance. Baozhen Wang MD. Early detection of cardiotoxicity (in the subclinical phase) as a sequela of cancer treatment results in less disability, higher quality of life, fewer future cardiac . 2007 Early Detection of Anthracycline Cardiotoxicity in Rabbits 537 beginning of the study) were used in this study. Am J Med 1978;65:823-32. The PTM was an effective laboratory procedure to avoid the progression to serious cardiomyopathy. early detection of cardiotoxicity. Anthracycline-induced cardiotoxicity can be detected at a preclinical phase. 2015 Jun;131(22):1981-8. BACKGROUND Anthracycline-induced cardiotoxicity is a major clinical problem, and early cardiotoxicity markers are needed. The findings have not been consistent amongst all studies. 2015;131(22):1981-8. SOURCE: Cardinale D, et al. Am J Cardiol 2011;107:1375-80. METHODS: Forty-four male rabbits were entered into the study. Most cardiotoxicity after anthracycline-containing therapy occurs within the first year and is associated with anthracycline dose and LVEF at the end of treatment. Early-onset cardiotoxicity usually occurs within hours to weeks but definitely during the first year after anthracycline administration, and can be reversible with early detection and treatment. Heloisa Sawaya Marielle Scherrer-Crosbie Assessment of echocardiography and biomarkers for the extended prediction of cardiotoxicity in patients treated with anthracyclines, taxanes, and trastuzumab. The animal experiments were performed in accordance with the Conclusions The use of cardiac biomarkers, particularly BNP, may allow early detection of cardiotoxicity related to anthracycline chemotherapy. Discovered in the 1960s, anthracyclines are still among the most widely used chemotherapy drugs, but are associated with cardiotoxicity. Early detection of anthracycline cardiotoxicity and improvement with heart failure therapy. The early detection rate of anthracycline-induced cardiotoxicity (3 months after chemotherapy) by GLS was 30.2% (95% CI: 24.9-36.1%), which is similar with the overall result of GLS. Purpose. Circulation. Background: Cardiotoxicity is a well-known and potentially serious complication of anticancer therapy. population treated with anthracycline (mean cumulative dose: 252 ± 86 mg/mq; range 30-900), close monitoring (every 3 months) of LVEF by standard echocardiography, during the first 12 months after the completion of chemotherapy, allowed early detection of almost all cases (98%) of cardiotoxicity, and Keywords Anthracyclines Cardiomyopathies Cardiotoxicity 1 With anthracyclines being so 419-423, 1999. Early detection and prediction of cardiotoxicity in chemotherapy-treated patients. There were no differences in any of the echocardiographic or blood markers at baseline between patients who did or did not develop cardiotoxicity. Von Hoff DD, Layard MW, Basa P, et al. August 2019. Eight rabbits were randomly selected to form control group (saline control). Early Detection of Anthracycline Cardiotoxicity and Improvement With Heart Failure Therapy. 81, no. Early Detection and Prediction of Cardiotoxicity in Chemotherapy-Treated Patients . Left ventricular ejection fraction (LVEF) is often inadequate to detect myocardial disease induced by chemotherapy. Mornos C, Petrescu L. Early detection of anthracycline-mediated cardiotoxicity: the value of considering both global longitudinal left ventricular strain and twist. Xu X, Persson HL, Richardson DR. Usefulness of the myocardial performance index for early detection of Anthracycline-induced cardiotoxicity in children Benjamin W. Eidem , Brian G. Sapp, Carlos R. Suarez, Frank Cetta Pediatric and Adolescent Medicine anthracycline or trastuzumab with imaging performed at baseline, and at 3, 6, 9, 12, and 15 months. It is recognized that anthracycline-mediated cardiotoxicity which often develops in the early stages following treatment initiation 8,9 is commonly reversible with appropriate medical intervention, while cardiotoxicity presenting following treatment completion is largely irreversible, suggesting early detection is essential to allow for the . Major Subject Heading (s) Early change in the GLS×LVtw index seems to be a good predictor of future development of anthracycline-induced cardiotoxicity. Circulation. Tjeerdsma G, Meinardi MT, van Der Graaf WT, van Den Berg MP, Mulder NH, Crijns HJ, de Vries EG, van Veldhuisen DJ: Early detection of anthracycline induced cardiotoxicity in asymptomatic patients with normal left ventricular systolic function: autonomic versus echocardiographic variables. This will inform the design of future therapeutic trials. Title:Prognostic Value of Cardiac Biomarkers Assessment in Combination with Myocardial 2D Strain Echocardiography for Early Detection of Anthracycline-Related Cardiac Toxicity Volume: 20 Issue: 1 Author(s): Mohammad P. Mahjoob, Seyed A. Sheikholeslami, Morvarid Dadras, Hamdollah Mansouri, Mahshid Haghi, Mohammadreza Naderian, Leila Sadeghi, Mohammadreza Tabary*Isa Khaheshi* This switch is controlled via a 4Fe-S cluster present within irp1 (figure 3). anthracycline cardiotoxicity. 2020 Mar 17;2(1):13-22. doi: 10.1016/j.jaccao.2020.01.007. Avila MS, Siqueira SRR, Ferreira SMA, Bocchi EA. Eidem BW, Sapp BG, Suarez CR, Cetta F (2001) Usefulness of the myocardial performance index for early detection of anthracycline-induced cardiotoxicity in children. Early detection of anthracycline cardiotoxicity and improvement with heart failure therapy. 24 Late-onset cardiotoxicity can present in a period of 10-20 years after treatment. Thus, carefully monitoring the development, early detection and prevention of cardiotoxicity, as well as understanding of the interaction between cancer and the cardiovascular system, thereby promoting the development of safer cancer therapeutics, without or with minimized cardiotoxicity, are urgently needed . Early detection and treatment are key to reducing morbidity and mortality in chemotherapy induced cardiotoxicity. The animals had free access to water and a standard laboratory pellet diet. Anthracycline-based chemotherapy represents the greatest risk. Early detection of cardiotoxicity is crucial for applying preventive and supp. Currently no diagnostic parameter is available allowing ubiquitous and reliable detection of preclinical anthracycline . Anthracyclines are important anticancer drugs, but their use is limited by cardiotoxicity. Optimizing the therapeutic antitumor and generate an increase in survival of patients treated. Early detection of anthracycline cardiotoxicity and improvement with heart failure therapy. Another method of detecting cardiotoxicity at an early stage may be the assessment of autonomic function. Tissue Doppler and bidimensional-strain imaging could detect . Early detection of cardiotoxicity and prevention of cardiovascular events is especially challenging in cancer patients receiving cardiotoxic chemotherapy. Speckle tracking echocardiography in the early detection and prediction of anthracycline cardiotoxicity in diffuse large B‐cell lymphoma treated with (R)‐CHOP regimen. early detection of myocardial dysfunction and prevention of overt heart failure are important3. Cardinale D, Colombo A, Bacchiani G, Tedeschi I, Meroni CA, Veglia F, et al. Experimental animals Anthracycline chemotherapy is the most effective treatment for breast cancer, soft tissue sarcomas, lymphomas, leukemias, and childhood solid tumors. The results do not support that assessment of cTnT or BNP levels may safely replace serial echocardiographic evaluation of systolic and diastolic function for the monitoring of anthracycline cardiotoxicity. Early detection of cardiotoxicity is crucial for applying preventive and supportive therapeutic strategies. CAS Article Google Scholar 21. Therefore, an iterative translational research program has been proposed to investigate biomarkers and mechanisms in pre-clinical models and move them . Literature Search: PubMed®, CINAHL®, Embase®, and Web of Science were searched in May 2018 . Bristow MR, Thompson PD, Martin RP, et al. Early Detection and Prediction of Anthracycline-Induced Right Ventricular Cardiotoxicity by 3-Dimensional Echocardiography JACC CardioOncol . These findings provide further evidence that our proposed panel of biomarkers and miRNAs can effectively detect the early onset of anthracycline induced cardiotoxicity before it is even apparent . Test for Early Detection of Heart Problems Reduces Cardiotoxicity Risk From Chemotherapy. Background: The main strategy for minimizing anthracycline cardiotoxicity is early detection of high-risk patients. Cardinale D, Colombo A, Sandri MT, et al. Download Prime PubMed App to iPhone, iPad, or Android Anthracycline therapy is a mainstay for breast cancer and many other cancers, but it is associated with a rate of incident heart failure more than five times the average. A systematic review of randomized controlled trials of dose-dense anthracycline-based chemotherapy in early breast cancer, comprising a meta-analysis that combined n = 1,310 patients, revealed that women who received a dose-dense chemotherapy regimen were not more likely to develop cardiotoxicity (OR = 0.5; 95 % CI = 0.05-5.54) . Anthracyclines are used to treat a broad range of malignancies. Cardinale D, Colombo A, Bacchiani G, Tedeschi I, Meroni CA, Veglia F, Civelli M, Lamantia G, Colombo N, Curigliano G, et al. Problem Identification: This review identifies specific cardiotoxicity related to anthracycline chemotherapy, specific risk factors related to increased anthracycline chemotherapy-induced cardiotoxicity, and underlying mechanisms of action of anthracycline chemotherapy-induced cardiotoxicity. Risk factors for doxorubicin-induced congestive heart failure. The PTM was superior to echocardiography for early, noninvasive detection and intermediate-term monitoring of left ventricle systolic function associated with anthracycline chemotherapy, among patients with hematologic malignancies. 2016 Jan 26;133(4):e361. A comment on this article appears in "Letter by Gallucci and Simeon Regarding Article, "Early Detection of Anthracycline Cardiotoxicity and Improvement With Heart Failure Therapy". This study aimed to determine whether early measurement of strain parameters derived by STE could predict the development of cardiotoxicity. 2013; 91(8) : 601 -7 PubMed Article CAS Google Scholar 10. Although there has been increasing recognition in recent years of the role of autonomic imbalance in the pathogen-esis of heart failure,12 13 up to now its value in anthracycline induced cardiotoxicity has Early detection of anthracycline cardiotoxicity and improvement with heart failure therapy. Early detection and prompt therapy of cardiotoxicity appear crucial for substantial recovery of cardiac function. Can J Physiol Pharmacol. The animal experiments were performed in accordance with the To date, the main strategies that seem to be effective in reducing its incidence and severity include screening and treating preexisting cardiovascular risk factors, limiting the cumulative anthracycline dose with a preference for less toxic analogues, and . Although brain natriuretic peptide (BNP) is not the ideal marker for detecting the presence of diseases of the heart, several studies have demonstrated the predictive utility of BNP in the diagnosis of anthracycline‑induced cardiotoxicity (AIC). The early detection rate of anthracycline-induced cardiotoxicity (3 months after chemotherapy) by GLS was 30.2% (95% CI: 24.9-36.1%), which is similar with the overall result of GLS.Conclusions: Hypert. Early detection of anthracycline cardiotoxicity and improvement with heart failure therapy. Cardinale D, Colombo A, Bacchiani G, et al. Early Detection and Serial Monitoring of Anthracycline-Induced Cardiotoxicity Using T1-mapping Cardiac Magnetic Resonance Imaging: An Animal Study /692/53/2421 /692 . The desired radiotracers allow early detection of myocyte injury and elucidate the mechanism of anthracycline-mediated cardiotoxicity. Anthracycline-based chemotherapy represents the greatest risk. When symptoms of heart failure are identified early, discontinuation of anthracycline followed by frequent monitoring of cardiac function can help to alleviate further decline. Circulation 2015;131:1981-8. 2013;91(8):601-7. The animals had free access to water and a standard laboratory pellet diet. AU Cardinale D, Colombo A, Bacchiani G, Tedeschi I, Meroni CA, Veglia F, Civelli M, Lamantia G, Colombo N, Curigliano G, Fiorentini C, Cipolla CM SO Circulation. Previous studies demonstrated that at the tissue level, early anthracycline toxicity is associated with myocardial inflammation, vacuolization, cell swelling, and oedema, and that these changes. Early detection of anthracycline cardiotoxicity and improvement with heart failure therapy. Circulation 2015; 131:1981. Early detection and prompt therapy of cardiotoxicity appear crucial for substantial recovery of cardiac function. They were housed under a 12 h light cycle, constant temperature and humidity. Because anthracycline-induced cardiotoxicity is a type I cardiotoxicity, detection of cardiomyocyte injury would be expected to identify those patients who may go on to develop left ventricular dysfunction. PubMed journal article: Early detection of anthracycline-induced cardiotoxicity using two-dimensional speckle tracking echocardiography. Probably, anthracycline-induced cardiotoxicity is a continuous phenomenon that starts from myocardial cell injury; it is followed by left ventricular ejection fraction (LVEF) and, if not diagnosed and cured early, progressively leads to symptomatic heart failure. Cardiotoxicity is a well-known complication that leads to substantial morbidity and often limits the utility of these agents. The aim of the present pilot study was therefore to explore and compare the potential of both the LV-filling pattern evaluation and plasma troponin T determination for an early detection of daunorubicin-induced cardiotoxicity in rabbits. They were housed under a 12 h light cycle, constant temperature and humidity. A more sensitive test capable of detecting heart function issues early . Although these advances have prolonged . Early Detection and Prediction of Cardiotoxicity in Chemotherapy-Treated Patients Heloisa Sawaya, MD, . OBJECTIVES The purpose of this study was to identify early doxorubicin-induced cardiotoxicity by serial multipara-metric cardiac magnetic resonance (CMR) and its pathological correlates in a large animal model. Jordan JH, Todd RM, Vasu S, Hundley WG. keywords = "anthracycline, cardiotoxicity, detection techniques, review, congestive-heart-failure, idiopathic dilated cardiomyopathy, advanced breast-cancer, left-ventricular dysfunction, acute lymphoblastic-leukemia, doppler-echocardiographic assessment, doxorubicin-induced cardiomyopathy, patients receiving doxorubicin, atrial-natriuretic . CAS Article Google Scholar 24. Cardinale D, Colombo A, Bacchiani G, et al. Detecting BNP after the final treatment of anthracycline chemotherapy may contribute to the early detection of cardiotoxicity. 10 anthracycline-induced cardiotoxicity, a pathophysiology based approach for early detection and protective strategies chapter 1 introduction and outline of the thesisintroduction 11 abundant intracellular iron. Early detection of anthracycline cardiotoxicity and improvement with heart failure therapy. Key Words: cardiotoxicity; cancer treatment; early detection J Nucl Med Technol 2013; 41:170-181 DOI: 10.2967/jnumed.110.082784 T he development of new antitumor agents, especially molecular targeting agents, has significantly improved the treatment options for cancer patients in the past decade. 2015 Jun 2;131(22):1981-8. Detailed Description: (25;26) irp2 shares extensive sequence homology with irp1, but lacks Prevention of high-dose chemotherapy-induced cardiotoxicity in highrisk patients by angiotensin-converting enzyme inhibition. A more sensitive test capable of detecting heart function issues early in cancer treatment may be beneficial in preventing heart failure. These data would imply that it may be important to detect anthracycline-induced cardiotoxicity early. Aim of the study: To investigate the role of cardiac biomarkers; cardiac troponin T (cTnT) and N-terminal probrain natriuretic peptide (NT-pro-BNP), and tissue Doppler imaging (TDI), as early predictors of Heart. Recently, cardiac magnetic resonance (CMR) has been successfully applied in the detection of post-treatment anthracycline-induced fibrosis through T1 mapping, paralleling decline in left ventricular ejection fraction (LVEF) 4 . An absolute decline in global longitudinal strain at 3 months of -19% had a Prognostic value of troponin I in cardiac risk stratification of cancer patients undergoing high-dose chemotherapy. "Early detection of anthracycline induced cardiotoxicity in asymptomatic patients with normal left ventricular systolic function: autonomic versus echocardiographic variables," Heart, vol. 2. Conclusions-Most cardiotoxicity after anthracycline-containing therapy occurs within the first year and is associated with anthracycline dose and LVEF at the end of treatment. Several guide-lines and recommendations for cardiotoxicity monitoring have been published 6, 7, including the American Heart Association (AHA)/American College of Cardiology (ACC) guidelines for anthracycline-induced cardiotoxic- Material and methods 2.1. Circulation. anthracycline treatment and the initial study time point was 3.5 months (range 2 to 144). CONCLUSIONS: Most cardiotoxicity after anthracycline-containing therapy occurs within the first year and is associated with anthracycline dose and LVEF at the end of treatment. Anthracycline-induced cardiotoxicity can be detected at a preclinical phase. Introduction Worldwide, breast cancer is the most common cancer and the first leading cause of cancer mortalities in women ( 1 ). . An earlier detection of adverse myocardial anthracycline chemotherapy would allow the adaptation of the regimen by reducing the number of interruptions of antitumor and strengthening monitoring. 1999, 81: 419-423. Alana Hippensteele, Editor. Several studies have demonstrated the importance of limiting anthracycline dose to minimize cardiotoxicity and cardiac mortality [ 13 ]. Cardinale D, Sandri MT, Colombo A, et al. Can J Physiol Pharmacol. Biomarkers, both currently used (for example, troponin and NTproBNP,) and more novel (for example, IL6, MPO, and sST2) will be assessed to see if early cardiomyopathy can be predicted. This study aimed to assess the early changes of left ventricular (LV) and right ventricular (RV) mechanics associated with anthracycline treatment for breast cancer and to determine whether two-dimensional speckle tracking echocardiography (2D-STE) analysis could predict chemotherapy-induced cardiotoxicity. Patients should be closely monitored for LV function during the first year after anthracycline chemotherapy. Early detection and prediction of cardiotoxicity in chemotherapy-treated patients. . Literature Search: PubMed®, CINAHL®, Embase®, and Web of Science were searched in May 2018 . Early anthracycline cardiotoxicity. Am J Cardiol 2011;107:1375-80. Problem Identification: This review identifies specific cardiotoxicity related to anthracycline chemotherapy, specific risk factors related to increased anthracycline chemotherapy-induced cardiotoxicity, and underlying mechanisms of action of anthracycline chemotherapy-induced cardiotoxicity. Cardinale D, Colombo A, Sandri MT, et al. 4, pp. Ann Intern Med 1979; 91:710. Prevention of high-dose chemotherapy-induced cardiotoxicity in highrisk patients by angiotensin-converting enzyme inhibition. A comment on this article appears in "Letter by Patanè Regarding Article, "Early Detection of Anthracycline Cardiotoxicity and Improvement With Heart Failure Therapy"." Circulation. Furthermore, close monitoring of cardiac function during this period allowed early detection and prompt treatment of cardiotoxicity, with major LVEF improvement in most cases. CAS PubMed Article Google Scholar 11.
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